Why MingCeler

Meet the Future of Mouse Model Creation

TurboMice™: To Inspire You To Do The Impossible

At Mingceler, we specialize in accelerating genetic research through our TurboMice™ technology, which harnesses optimized tetraploid complementation to deliver fully homozygous mouse models in just 2–4 months—60% faster than traditional breeding methods. Unlike conventional approaches that require 6–12 months of tedious breeding cycles, our process starts with precision editing of embryonic stem cells (ESCs) for targeted gene knockouts, floxing, or multi-locus modifications. We then use tetraploid complementation to develop these ESCs directly into experiment-ready mice, skipping the need for chimeric F1 and F2 generations. This method ensures 100% genotype certainty from the F0 generation, eliminating the guesswork of heterozygous screening and saving researchers thousands of hours spent on colony management.

The Once Technically Impossible – Engineered to Reality with TurboMice™

What is tetraploid complementation and TurboMice™?

The tetraploid complementation assay is a technique in biology in which cells of two mammalian embryos are combined to form a new embryo. It is used to construct genetically modified organisms, to study the consequences of specific mutations on embryonic development, and to study pluripotent stem cells.

TurboMice™ is our patented Tetraploid Complementation Technology (TCT) for generating aggregated blastocysts (no microinjections, non-chimeric embryos).

How fast is TCT?

Extremely fast. Homozygousmodels in just 2 - 4 months, skipping long initial breeding. This speeds up research from pilot to full - scale studies.

Are TCT-produced mice viable long-term, and do I need to repeat steps for each batch?

TCT-produced mice are genetically stable and fully fertile, making them ideal for long-term research and breeding programs. In the rare case that the targeted gene impacts fertility, TCT offers a distinct advantage: it enables the generation of unlimited homozygous mice in just 45 days.

The Game-changing Benefits

While competitors only highlight their improvements to traditional approaches—marginal germline efficiency gains, 99.9% chimerism, or incremental ESC-based advantages—our proprietary technology delivers a transformative leap in in animal model technology. We generate fully pure, homogeneous lineages: every single cell of our mice is derived exclusively from totipotent ES cells, with 100% guaranteed germline transmission efficiency. Experience these unparalleled benefits firsthand: enquire about your custom mouse model project with us, or order embryos for in-house validation at your facility.

Why TCT over CRISPR or Traditional microinjection?

CRISPR is inherently hit-or-miss with off-target effects, while any ES cell microinjection yields genetically mosaic, high-chimerism mouse models. Both demand lengthy multi-generational breeding to isolate stable strains. In stark contrast, our proprietary TCT (Tetraploid Complementation Technology) offers a game-changing 100% breeding-free solution—fully homogeneous, non-chimeric models with guaranteed pure genomic edits, no off-target risks.

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ES bank

Enhanced Reproducibility

By removing genetic variability, results become more reliable and reproducible. In drug testing, identical mice respond uniformly to treatments, enabling precise cross-lab replication. This strengthens scientific credibility, supports cross-validation, and is vital for discoveries based on stable experimental conditions.
Improved Predictability

With the same DNA in every mouse, researchers can accurately anticipate physical and behavioral traits. In disease modeling, such as Alzheimer’s or cancer, consistent genetic backgrounds yield dependable symptom patterns. This simplifies result interpretation, reduces experimental uncertainty, and enables targeted, efficient studies, streamlining research.
Efficient Drug Screening and Development

High-throughput, well-controlled experiments are possible since all mice share identical genetic profiles. Any variation in drug response can be attributed to the drug, not genetics. This accelerates the identification of effective compounds, reduces false positives, and cuts development costs, shortening pre-clinical timelines for faster human trials.
In - depth Genetic Research

The absence of genetic variability provides a clean background for targeted gene modifications. Researchers can introduce or disable specific genes to observe precise biological effects—crucial in cancer and developmental biology for uncovering gene-disease mechanisms and paving the way for new therapies.

MingCeler Mouse Custome

TurboMice™ Knockout Mice

Homozygous mice: 2~4 months
3Rs benefit: no chimeras, no breeding selection required.
Please Enter the number of Mice and Sex in the Requirements Section
TurboMice™ Knock in Mice

• Targeted at a ‘Rosa26/H11’ locus
• Reporter mice
Any target site you wish to knock in
Homozygous mice: 3~5 months
3Rs benefit: no chimeras, no breeding selection required.
Please Enter the number of Mice and Sex in the Requirements Section
TurboMice™ Humanized Mice

• Humanizing point mutations
• Humanizing domains, such as extracellular domains
• Humanizing the entire gene
• Humanizing multi-gene loci
Unrivaled speed and convenience
Homozygous mice: 3~5 months
3Rs benefit: no chimeras, no breeding selection required
Please Enter then umber of Mice and Sex in the Requirements Section
TurboMice™ Conditional knockout Mice

Homozygous mice: 4~6 months（Cre+fl/fl）
3Rs benefit: no chimeras, no breeding selection required
Please Enter thenumber of Mice and Sex in the Requirements Section

TurboMice™ Point Mutant Mice

Homozygous mice: 3~5 months
3Rs benefit: no chimeras, no breeding selection required
Please Enter thenumber of Mice and Sex in the Requirements Section
TurboMice™ Multi-Site Gene Editing Mice

Homozygous mice: 4~6 months
3Rs benefit: no chimeras, no breeding selection required
Please Enter thenumber of Mice and Sex in the Requirements Section
TurboMice™ Transgenic Mice

Homozygous mice: 3~5 months
3Rs benefit: no chimeras, no breeding selection required
Please Enter thenumber of Mice and Sex in the Requirements Section

Case Study

Highly cooperative chimeric super-SOX induces naive pluripotency across species	Journal：Cell stem cell	IF=19.8
Rapid generation of ACE2 humanized inbred mouse model for COVID-19 with tetraploid complementation	Journal：National Science Review	IF=16.3
Dalbavancin binds ACE2 to block its interaction with SARS-CoV-2 spike protein and is effective in inhibiting SARS-CoV-2 infection in animal models	Journal：Cell Research	IF=25.9
SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target	Journal：Cell Research	IF=28.1
Captopril alleviates lung inflammation in SARS-CoV-2-infected hypertensive mice	Journal：Zoological Research	IF=4.7

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