Obtain homozygous mice in 2 months

MingCelerKnockout

KO

Gene knockout mice (KO) are animal models developed through gene editing technology to completely remove a target gene from the genome, resulting in a total loss of its function. They are widely used in gene function research, disease mechanism investigation, and drug target validation.
MingCeler Biotech employs the TurboMice™ tetraploid complementation technique to construct gene knockout mice, enabling the generation of mice from cells in a single step.TurboMice™ technology breaks through the technical difficulties of long mouse modeling cycle and low success rate of complex models. It can realize the editing of almost any target gene locus.

Our advantages

01

Zero animal waste, 3R-compliant: All F0 mice can be directly used in experiments. There's no breeding waste, significantly reducing the number of animals used in experiments, embodying the 3Rs principle (Reduce, Refine, Replace).
02

Totipotency Unleashed: TurboMice™ bypasses the need for fertilized egg or embryo injection, enabling ES cells to develop into complete mice. This not only increases success rates but also averts the creation of chimeras resulting from host embryo cells.
03

Unlimited Production via Tetraploid Technology: Leveraging our proprietary tetraploid compensation patented technology, we can theoretically clone edited ES cells infinitely. This allows us to generate a large number of experimental mice, offering 200 pairs or more of homozygotes in one go to meet extensive experimental demands without resource waste.
04

Matching CRISPR's Speed, Zero Off-Target： Our optimized homologous recombination technology targets ES cells. It allows for simultaneous multi-gene editing, cutting project time, and outpacing traditional mouse model generation methods in speed. We provide a guarantee of no off-target effects, ensuring 100% accurate (on the DNA level) and reliable gene-editing results.

TurboMice™ Deliverables

Strategy design

1-2 days
Molecular vector construction

2-4 weeks
Cell editing and screening

2-4 weeks
Tetraploid mouse production

3-4 weeks
Weaning and transportation

3 weeks

Achieve target homozygous
Gene knockout mouse strain

Only 2-4 months

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Customized Genetic Models with Guaranteed Homozygosity—No Breeding Required

Guarantee

Mingceler provides the industry's most robust guarantee: successful generation of genetically engineered mice. Should we fail to deliver animals with the specified genotype, the client’s service fee will be fully refunded*.

*Exclusions apply for genetic modifications that severely compromise viability, morbidity, or fertility due to intrinsic biological constraints.

Case Study

Rapid generation of ACE2 humanized inbred mouse model for COVID-19 with tetraploid complementation

journal：National Science Review

IF=16.3

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Online Quotation

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KO CKO KI CKI Humanize PM Transgenic IVF other
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Alternatively, call us at 400-8388-113 or reach technical support at 18126776342 (also available on WeChat).