directly edits the sites into the embryonic stem cells of mice

MingCelerKnock-In

Knock-in

Knock-in mice (KI) are genetically engineered models in which an exogenous functional gene is precisely inserted into a specific genomic locus via homologous recombination, enabling stable and persistent expression within cells. Mingxun Biotech employs the TurboMice™ tetraploid complementation technique to efficiently generate knock-in mice. MingCeler Biotech offers customized precision Rosa26 KI and H11 KI mouse models—both recognized as "safe harbor" sites. These ensure stable, widespread, and predictable expression of the inserted gene across various tissues, without compromising the health of the mice. Using our advanced platform, homozygous KI mice can be generated directly from engineered cells in a single step, with a model development cycle as short as three months, significantly accelerating your research progress.

TurboMice™ Deliverables

Strategy design

1-2 days
Molecular vector construction

2-4 weeks
Cell editing and screening

4-6 weeks
Tetraploid mouse production

4-6 weeks
Weaning and transportation

3 weeks

Achieve target homozygous
Gene knock-in mouse turnaround time

Only 3-5 months

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Customized Genetic Models with Guaranteed Homozygosity—No Breeding Required

Guarantee

Mingceler provides the industry's most robust guarantee: successful generation of genetically engineered mice. Should we fail to deliver animals with the specified genotype, the client’s service fee will be fully refunded*.

*Exclusions apply for genetic modifications that severely compromise viability, morbidity, or fertility due to intrinsic biological constraints.

Online Quotation

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KO CKO KI CKI Humanize PM Transgenic IVF other
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5 10 20 other
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Alternatively, call us at 400-8388-113 or reach technical support at 18126776342 (also available on WeChat).