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MingCelerNeuro Model
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Research in the fields of neuroscience, Alzheimer's disease, and amyloid metabolismAPP KO miceApplicationAlzheimer's Disease Research: Investigate the impact of complete deficiency of the amyloid precursor protein (APP) on Alzheimer's disease-related pathologies, such as amyloid plaque formation, synaptic dysfunction, and cognitive decline. Explore the central role of APP in the generation, processing, and toxic effects of β-amyloid. Neurodevelopment and Plasticity: Investigate the physiological roles of APP in neuronal development, synaptogenesis, plasticity, and cognitive function. Study the effects of APP knockout on learning and memory, neural circuit function, and behavioral performance. Drug Development and Therapeutic Strategies: Evaluate the potential impacts and side effects of therapeutic strategies targeting the APP/Aβ pathway in the context of APP deficiency. Investigate the non-Aβ dependent physiological functions of APP, providing clues for novel therapeutic targets.FeaturesComplete knockout of the APP gene encoding the amyloid precursor protein, providing a key genetic tool for studying its physiological functions and central role in Alzheimer's disease pathology.Learn more
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Research in the fields of neuroscience, neurodegenerative diseases, and cytoskeletal biologyMapt KO miceApplicationNeurodegenerative Disease Research: Investigate the impact of Tau protein (encoded by the Mapt gene) deficiency on the pathogenesis and progression of tauopathies, such as Alzheimer's disease, frontotemporal dementia, and progressive supranuclear palsy. Explore the mechanisms of Tau protein in neurofibrillary tangle formation, axonal transport, and synaptic dysfunction. Basic Neuroscience: Investigate the physiological functions of Tau protein in neuronal development, cytoskeletal stability, microtubule assembly, and transport. Study the effects of Tau deficiency on synaptic plasticity, learning, and memory functions. Drug Development: Evaluate the efficacy and safety of therapeutic strategies targeting the Tau pathway (e.g., aggregation inhibitors, microtubule stabilizers) in the context of complete Tau knockout.FeaturesComplete knockout of the Mapt gene encoding Tau protein, providing a key genetic tool for studying the physiological and pathological functions of Tau.Learn more
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Alternatively, call us at 400-8388-113 or reach technical support at 18126776342 (also available on WeChat).
