•Complete Human Gene Replacement
Replace entire mouse genes with human counterparts while retaining native murine promoters
Enables physiological human gene expression patterns in mouse
•Multi-Gene Locus Humanization
Simultaneous replacement of multiple contiguous genes
Capable of handling fragments up to several hundred kilobases per project
•Domain Humanization
Targeted replacement of specific functional domains (e.g., extracellular domains)
Preserves mouse gene architecture while introducing human functional elements
•Point Mutation Humanization
Replace specific mouse gene nucleotides with human equivalents
Ideal for modeling single-nucleotide polymorphisms (SNPs) and disease-causing mutations

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All model generation projects of Mingceler operate under a fee-for-service framework.
IP Ownership: All intellectual property rights related to custom mouse models, including derived organs, tissues, cells, and biological materials, are the sole and exclusive property of the Client.
Third-Party Transfer Permission: The Client may independently decide to retain, utilize, or commercialize their custom models project materials (e.g., targeting vectors, ES cells, mouse lines) without the need for prior consent from Mingceler.
Licensing Exemption: The Client has full autonomy over all uses of the custom models or their derivatives, including but not limited to commercialization, distribution to third parties, and publication involving model data. No written license from Mingceler is required for such uses.