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ACE2 Humanized Mouse
Endogenous Research
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*Any publication resulting from the use of this strain must cite/acknowledge Guangzhou MingCeler Biotechnology Co., Ltd.
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Genotype
Heterozygous
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Strain Description
Humans and mice have differences in the ACE2 protein sequence. The native mouse ACE2 receptor does not bind the SARS-CoV-2 spike protein with high affinity, making standard laboratory mice naturally resistant to infection. The ACE2 humanized mouse model overcomes this critical species barrier.
The most common approach involves inserting the full-length human ACE2gene, often under the control of its own promoter or a ubiquitous promoter, into the mouse genome. This ensures the human protein is expressed in relevant tissues such as the lungs, heart, kidneys, and intestines—mirroring the expression pattern in humans.
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qHow long does it take to generate a mouse model?a• Mingceler delivers novel mouse models in an average of 24 weeks.
• From scratch, we deliver experiment-ready homozygous target mice (F0) in as fast as 12 weeks.
• Please see our timelines for more information.
Mingceler continuously optimizes project timelines through Lean management principles—stabilizing, standardizing, and refining each process. Our proprietary TurboMice™ technology exemplifies this refinement, enabling rapid generation of genetically engineered mice with industry-leading efficiency while significantly enhancing animal welfare.
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We offer tailored gene editing solutions—get a free quote instantly.
Fill out the form, and we will contact you within two business days.
Alternatively, call us at 400-8388-113 or reach technical support at 18126776342 (also available on WeChat).
Fill out the form, and we will contact you within two business days.
Alternatively, call us at 400-8388-113 or reach technical support at 18126776342 (also available on WeChat).
