This mouse strain is generated through gene editing technology to specifically knockout the ubiquitin-specific protease 7 (Usp7, also known as HAUSP) gene. USP7 is a crucial deubiquitinating enzyme that regulates the stability, localization, and activity of numerous key proteins by removing ubiquitin chains from target substrates. These targets include tumor suppressors (e.g., p53, PTEN), epigenetic regulators (e.g., EZH2, DNMT1), viral proteins, and immune regulatory proteins. USP7 is widely involved in processes such as cell cycle regulation, DNA damage response, epigenetic modification, immune response, and viral latency. This model provides a key tool for in-depth in vivo investigation of the specific mechanisms by which USP7 maintains protein homeostasis, regulates cell fate decisions, influences tumorigenesis and progression, and modulates neuroimmune functions. It serves as a foundational research model for exploring therapeutic strategies targeting USP7.